Marginal Zone B-Cell lymphoma (MALToma) | Indolent B-Cell Non-Hodgkin’s Lymphoma
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Hematological malignancies can be divided into leukemias, lymphomas, and multiple myeloma.
Lymphomas can be divided into Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.
Non-Hodgkin’s lymphoma can be subdivided into aggressive lymphoma and indolent lymphoma.
Aggressive non-Hodgkin’s lymphoma includes:
*Diffuse large B-cell lymphoma (DLBCL)
*Mantle cell lymphoma.
*Precursor T-cell lymphoblastic lymphoma.
Indolent non-Hodgkin’s lymphomas include:
*Marginal zone B-cell lymphoma (MALToma)
*Hairy cell leukemia/ lymphoma.
*Mycosis fungoides/ Sezary syndrome.
Marginal Zone B-cell lymphoma is an indolent (low grade) Non-Hodgkin’s Lymphoma…It can be nodal, extranodal, or splenic. The extranodal is also known as Mucosa-associated lymphatic tissue lymphoma (MALToma). It can have B (constitutional) symptoms such as unintentional weight loss, night sweats, and fever.
Marginal zone B-cell lymphoma can transform into diffuse large B-cell lymphoma (aggressive NHL).
MALT lymphoma can have (11;18) translocation
For diagnosis, you need a core needle biopsy or an excisional biopsy of the lymph node, stomach, salivary gland, ….etc.
Treat with the “watch and wait” approach, radiation or chemotherapy depending on the stage.
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